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Article

UNG protects B cells from AID-induced telomere loss

3 Oct 2016

Abstract excerpt

Activation-induced deaminase (AID) initiates antibody gene diversification by creating G:U mismatches in the immunoglobulin loci. However, AID also deaminates nonimmunoglobulin genes, and failure to faithfully repair these off-target lesions can cause B cell lymphoma. In this study, we identify a mechanism by which processing of G:U produced by AID at the telomeres can eliminate B cells at risk of genomic...

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Identifiers

PMID: 27697833
DOI: 10.1084/jem.20160635

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