Article
The mismatch repair pathway functions normally at a non-AID target in germinal center B cells.
Blood - 15 Sept 2011
Green Blerta, Belcheva Antoaneta, Nepal Rajeev M, Boulianne Bryant, Martin Alberto
Abstract excerpt
Deficiency in Msh2, a component of the mismatch repair (MMR) system, leads to an approximately 10-fold increase in the mutation frequency in most tissues. By contrast, Msh2 deficiency in germinal center (GC) B cells decreases the mutation frequency at the IgH V region as a dU:dG mismatch produced by AID initiates modifications by MMR, resulting in mutations at nearby A:T base pairs. This raises the possibility...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.