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A review of the genetic effects of ethyl methanesulfonate.

Mutation research - 1 Jan 2000

Sega G A

Abstract excerpt

Ethyl methanesulfonate (EMS) is a monofunctional ethylating agent that has been found to be mutagenic in a wide variety of genetic test systems from viruses to mammals. It has also been shown to be carcinogenic in mammals. Alkylation of cellular, nucleophilic sites by EMS occurs via a mixed SN1/SN2 reaction mechanism. While ethylation of DNA occurs principally at nitrogen positions in the bases, because of the...

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PMID: 6390190
DOI: 10.1016/0165-1110(84)90007-1

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