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Article

A review of the genetic effects of ethyl methanesulfonate.

Mutation research - 1 Jan 2000

Sega G A

Abstract excerpt

Ethyl methanesulfonate (EMS) is a monofunctional ethylating agent that has been found to be mutagenic in a wide variety of genetic test systems from viruses to mammals. It has also been shown to be carcinogenic in mammals. Alkylation of cellular, nucleophilic sites by EMS occurs via a mixed SN1/SN2 reaction mechanism. While ethylation of DNA occurs principally at nitrogen positions in the bases, because of the...

Topics

Animals
Bacteria
Cell Line
Cricetinae
DNA Replication
Ethyl Methanesulfonate
Female
Fungi
Genes
Genes, Dominant
Genes, Lethal
Humans
Insecta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mutagenicity Tests

Mutagens

Mutation

Source

Identifiers

PMID: 6390190
DOI: 10.1016/0165-1110(84)90007-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6390190-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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