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Article

Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents.

Mutagenesis - 1 May 2013

Taira Kentaro, Kaneto Satomi, Nakano Kota, Watanabe Shinji, Takahashi Eizo, Arimoto Sakae, Okamoto Keinosuke, Schaaper Roel M, Negishi Kazuo, Negishi Tomoe

Abstract excerpt

DNA alkylation damage can be repaired by nucleotide excision repair (NER), base excision repair (BER) or by direct removal of alkyl groups from modified bases by O(6)-alkylguanine DNA alkyltransferase (AGT; E.C. 2.1.1.63). DNA mismatch repair (MMR) is also likely involved in this repair. We have investigated alkylation-induced mutagenesis in a series of NER- or AGT-deficient Escherichia coli strains, alone or in...

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Identifiers

PMID: 23446177
DOI: 10.1093/mutage/get010
PMCID: PMC3630523

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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