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Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine Deamination

15 Aug 2006

Abstract excerpt

The human cytidine deaminases APOBEC3G (hA3G) and APOBEC3F (hA3F) are intracellular antiretroviral factors that can hypermutate nascent reverse transcripts and inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Both enzymes have two cytidine deaminase motifs, although only the C-terminal motif is catalytic. Current models of APOBEC protein function imply editing is the principal mechanism of...

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PMID: 16912295
DOI: 10.1128/jvi.00839-06

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Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine DeaminationPMID 16912295Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

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