Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulated Production and Anti-HIV Type 1 Activities of Cytidine Deaminases APOBEC3B, 3F, and 3G

1 Jul 2005

Abstract excerpt

APOBEC3G and 3F (A3G and A3F) cytidine deaminases incorporate into retroviral cores where they lethally hypermutate nascent DNA reverse transcripts. As substantiated here, the viral infectivity factor (Vif) encoded by human immunodeficiency virus type-1 (HIV-1) binds A3G and A3F and induces their degradation, thereby precluding their incorporation into viral progeny. Previous evidence suggested that A3G is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16060832
DOI: 10.1089/aid.2005.21.611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulated Production and Anti-HIV Type 1 Activities of Cytidine Deaminases APOBEC3B, 3F, and 3GPMID 16060832Read ↗

Inhibition of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{tRNA}_{3}^{\mathrm{Lys}}\) \end{document}-Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 ReplicationSemantic proximity Read ↗

Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction FactorsSemantic proximity Read ↗

APOBEC3G and APOBEC3F Require an Endogenous Cofactor to Block HIV-1 ReplicationSemantic proximity Read ↗

Inhibition of initiation of reverse transcription in HIV-1 by human APOBEC3FSemantic proximity Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.Semantic proximity Read ↗

APOBEC3G inhibits elongation of HIV-1 reverse transcripts.Semantic proximity Read ↗

Stably Expressed APOBEC3F Has Negligible Antiviral ActivitySemantic proximity Read ↗

APOBEC3G-Mediated G-to-A Hypermutation of the HIV-1 Genome: The Missing Link in Antiviral Molecular MechanismsSemantic proximity Read ↗

T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase ActivitySemantic proximity Read ↗

Cytidine Deaminases APOBEC3G and APOBEC3F Interact with Human Immunodeficiency Virus Type 1 Integrase and Inhibit Proviral DNA FormationSemantic proximity Read ↗

Moderate Influence of Human APOBEC3F on HIV-1 Replication in Primary LymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.