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APOBEC3G & HTLV-1: Inhibition without deamination

29 May 2005

Abstract excerpt

APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines. Inhibition of HIV-1 replication is thought to be the result of APOBEC3G-induced hypermutation of the viral genome that occurs early during reverse transcription. Against this backdrop...

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PMID: 15921532
DOI: 10.1186/1742-4690-2-37

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APOBEC3G & HTLV-1: Inhibition without deaminationPMID 15921532Read ↗

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