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Article

Moderate Influence of Human APOBEC3F on HIV-1 Replication in Primary Lymphocytes

1 Jul 2010

Abstract excerpt

Multiple APOBEC3 proteins are expressed in HIV-1 target cells, but their individual contributions to viral suppression when expressed at endogenous levels remain largely unknown. We used an HIV NL4-3 mutant that selectively counteracts APOBEC3G (A3G) but not APOBEC3F (A3F) to dissect the relative contribution of A3F to the inhibition of HIV-1 replication in primary human lymphocytes (peripheral blood mononuclear...

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Identifiers

PMID: 20592068
DOI: 10.1128/jvi.02630-09

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