Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.

The Journal of biological chemistry - 26 Jan 2007

Holmes Rebecca K, Koning Fransje A, Bishop Kate N, Malim Michael H

Abstract excerpt

APOBEC3F (apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1-like protein 3F) is a cytidine deaminase that, like APOBEC3G, is able to restrict the replication of HIV-1/delta vif. Initial studies revealed high numbers of mutations in the cDNA of viruses produced in the presence of these proteins, suggesting that cytidine deamination underpinned the inhibition of infection. However, we have recently shown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOBEC-3G Deaminase

Share to Cytidine Deaminase

Share to Cytosine Deaminase

Share to Reverse Transcription

Share to Virus Assembly

Share to Virus Replication

Source

Identifiers

PMID: 17121840
DOI: 10.1074/jbc.M607298200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.PMID 17121840Read ↗

Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4 <sup>+</sup> T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine DeaminationSemantic proximity Read ↗

Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.Semantic proximity Read ↗

Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity.Semantic proximity Read ↗

Cytidine Deaminases APOBEC3G and APOBEC3F Interact with Human Immunodeficiency Virus Type 1 Integrase and Inhibit Proviral DNA FormationSemantic proximity Read ↗

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous RetroelementsSemantic proximity Read ↗

Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.Semantic proximity Read ↗

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.Semantic proximity Read ↗

APOBEC3G inhibits elongation of HIV-1 reverse transcripts.Semantic proximity Read ↗

Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine DeaminationSemantic proximity Read ↗

Leveraging APOBEC3 Proteins to Alter the HIV Mutation Rate and Combat AIDSSemantic proximity Read ↗

Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2.Semantic proximity Read ↗

Functional domains of APOBEC3G required for antiviral activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.