Article
Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2010
Kohlmann Alexander, Grossmann Vera, Klein Hans-Ulrich, Schindela Sonja, Weiss Tamara, Kazak Beray, Dicker Frank, Schnittger Susanne, Dugas Martin, Kern Wolfgang, Haferlach Claudia, Haferlach Torsten
Abstract excerpt
PURPOSE: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that is characterized by features of both a myeloproliferative neoplasm and a myelodysplastic syndrome. Thus far, data on a comprehensive cytogenetic or molecular genetic characterization are limited. PATIENTS AN...
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