Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients.

doi:10.1038/s41375-019-0690-7

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Article

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients.

Leukemia - 1 May 2020

Coltro Giacomo, Mangaonkar Abhishek A, Lasho Terra L, Finke Christy M, Pophali Prateek, Carr Ryan, Gangat Naseema, Binder Moritz, Pardanani Animesh, Fernandez-Zapico Martin, Robertson Keith D, Bosi Alberto, Droin Nathalie, Vannucchi Alessandro M, Tefferi Ayalew, Hunter Anthony, Padron Eric, Solary Eric, Patnaik Mrinal M

Abstract excerpt

Loss-of-function TET2 mutations (TET2MT) are frequent early clonal events in myeloid neoplasms and are thought to confer a fitness advantage to hematopoietic precursors. This large, multi-institutional study (n = 1084), investigated the TET2 mutational landscape and prognostic implications of the number, type, and location of TET2MT and the epistatic relationship with other somatic events in chronic...

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PMID: 31836856
DOI: 10.1038/s41375-019-0690-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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