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Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance

23 Sept 2016

Abstract excerpt

TET2 , located on chromosome 4q24, is frequently mutated (~60%) in patients with chronic myelomonocytic leukemia (CMML). 1 , 2 TET2 has 11 exons, and variations, especially in exon 3 have been described as a part of age-related clonal hematopoiesis. 3 In a large population-based study ( n =17 182), somatic variations involving DNMT3A , TET2 and ASXL1 were seen in ~11% of the population >80 years of age, and in...

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PMID: 27662201
DOI: 10.1038/bcj.2016.82

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