Article
Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.
Annals of clinical and laboratory science - 1 Jan 2010
Yin De-Tao, Wang Lin, Sun Jianrei, Yin Fengyan, Yan Qingtao, Shen Ru-Long, Gao Jian-Xin, He Gang
Abstract excerpt
The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. FHIT is considered to be a tumor suppressor gene that is frequently inactivated in various types of cancer. To study the role of the FHIT gene in thyroid tumorigenesis, we looked for homozygous deletions or mutations of exons 5 and...
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