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Article

Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.

Annals of clinical and laboratory science - 1 Jan 2010

Yin De-Tao, Wang Lin, Sun Jianrei, Yin Fengyan, Yan Qingtao, Shen Ru-Long, Gao Jian-Xin, He Gang

Abstract excerpt

The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors. FHIT is considered to be a tumor suppressor gene that is frequently inactivated in various types of cancer. To s...

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Share to Acid Anhydride Hydrolases
Share to Chromosome Fragile Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 20689140

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20689140-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.PMID 20689140Read ↗

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Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea.Semantic proximity Read ↗

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.Semantic proximity Read ↗

Anomalous transcripts and allelic deletions of the FHIT gene in human esophageal cancer.Semantic proximity Read ↗

Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions.Semantic proximity Read ↗

FHITness and cancer.Semantic proximity Read ↗

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.Semantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma.Semantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

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