Article
Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.
Microbiology (Reading, England) - 1 Nov 2010
Driessen Nicole N, Stoop Esther J M, Ummels Roy, Gurcha Sudagur S, Mishra Arun K, Larrouy-Maumus Gérald, Nigou Jérôme, Gilleron Martine, Puzo Germain, Maaskant Janneke J, Sparrius Marion, Besra Gurdyal S, Bitter Wilbert, Vandenbroucke-Grauls Christina M J E, Appelmelk Ben J
Abstract excerpt
Lipoarabinomannan (LAM) is a major glycolipid in the mycobacterial cell envelope. LAM consists of a mannosylphosphatidylinositol (MPI) anchor, a mannan core and a branched arabinan domain. The termini of the arabinan branches can become substituted with one to three α(1→2)-linked mannosyl residues, the mannose cap, producing ManLAM. ManLAM has been associated with a range of different immunomodulatory properties...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.