Article
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2006
Kaur Devinder, Berg Stefan, Dinadayala Premkumar, Gicquel Brigitte, Chatterjee Delphi, McNeil Michael R, Vissa Varalakshmi D, Crick Dean C, Jackson Mary, Brennan Patrick J
Abstract excerpt
Lipoarabinomannan (LAM), one of the few known bacterial glycosylphosphoinositides (GPIs), occurs in various structural forms in Mycobacterium species. It has been implicated in key aspects of the physiology of Mycobacterium tuberculosis and the immunology and pathogenesis of tuberculosis. Yet, little is known of the biosynthesis of LAM. A bioinformatics approach identified putative integral membrane proteins,...
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