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Article

Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.

Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2008

Kaur Devinder, Obregón-Henao Andrés, Pham Ha, Chatterjee Delphi, Brennan Patrick J, Jackson Mary

Abstract excerpt

Biosynthesis of phosphatidylinositol (PI)-containing lipoarabinomannan (LAM) and lipomannan (LM) of Mycobacterium spp. follows a conserved pathway involving multiple membrane-associated, substrate-specific mannosyltransferases (ManTs) responsible for the sequential addition of alpha-mannopyranosyl (Manp) units donated by decaprenyl-P-Manp on the periplasmic side of the plasma membrane. Because of their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19004785
DOI: 10.1073/pnas.0807761105
PMCID: PMC2584715

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