Article
The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction.
Cellular microbiology - 1 Apr 2008
Appelmelk B J, den Dunnen J, Driessen N N, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha S S, Movahedzadeh F, Geurtsen J, Brown E J, Eysink Smeets M M, Besra G S, Willemsen P T J, Lowary T L, van Kooyk Y, Maaskant J J, Stoker N G, van der Ley P, Puzo G, Vandenbroucke-Grauls C M J E, Wieland C W, van der Poll T, Geijtenbeek T B H, van der Sar A M, Bitter W
Abstract excerpt
Pathogenic mycobacteria have the ability to persist in phagocytic cells and to suppress the immune system. The glycolipid lipoarabinomannan (LAM), in particular its mannose cap, has been shown to inhibit phagolysosome fusion and to induce immunosuppressive IL-10 production via interaction with the mannose receptor or DC-SIGN. Hence, the current paradigm is that the mannose cap of LAM is a crucial factor in...
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