Article
Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae.
The Journal of biological chemistry - 14 Mar 2008
Lea-Smith David J, Martin Kirstee L, Pyke James S, Tull Dedreia, McConville Malcolm J, Coppel Ross L, Crellin Paul K
Abstract excerpt
The cell walls of the Corynebacterineae, which includes the important human pathogen Mycobacterium tuberculosis, contain two major lipopolysaccharides, lipoarabinomannan (LAM) and lipomannan (LM). LAM is assembled on a subpool of phosphatidylinositol mannosides (PIMs), whereas the identity of the LM lipid anchor is less well characterized. In this study we have identified a new gene (Rv2188c in M. tuberculosis...
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