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Article

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.

The Journal of biological chemistry - 31 Dec 2010

Skovierová Henrieta, Larrouy-Maumus Gérald, Pham Ha, Belanová Martina, Barilone Nathalie, Dasgupta Arunava, Mikusová Katarina, Gicquel Brigitte, Gilleron Martine, Brennan Patrick J, Puzo Germain, Nigou Jérôme, Jackson Mary

Abstract excerpt

The arabinogalactan (AG) of slow growing pathogenic Mycobacterium spp. is characterized by the presence of galactosamine (GalN) modifying some of the interior branched arabinosyl residues. The biosynthetic origin of this substituent and its role(s) in the physiology and/or pathogenicity of mycobacteria are not known. We report on the discovery of a polyprenyl-phospho-N-acetylgalactosaminyl synthase (PpgS) and the...

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Identifiers

PMID: 21030587
DOI: 10.1074/jbc.M110.188110
PMCID: PMC3009860

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