Article
Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.
Journal of bacteriology - 1 Nov 2009
Scherman Hataichanok, Kaur Devinder, Pham Ha, Skovierová Henrieta, Jackson Mary, Brennan Patrick J
Abstract excerpt
We report on the identification of a glycosyltransferase (GT) from Mycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo-inositol mannosides.
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