Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.

The Journal of biological chemistry - 19 Sept 2003

Korduláková Jana, Gilleron Martine, Puzo Germain, Brennan Patrick J, Gicquel Brigitte, Mikusová Katarina, Jackson Mary

Abstract excerpt

Fatty acyl functions of the glycosylated phosphatidylinositol (GPI) anchors of the phosphatidylinositol mannosides (PIM), lipomannan (LM), and lipoarabinomannan (LAM) of mycobacteria play a critical role in both the physical properties and biological activities of these molecules. In a search for the acyltransferases that acylate the GPI anchors of PIM, LM, and LAM, we examined the function of the mycobacterial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Cell-Free System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mannose

Share to Mycobacterium

Share to Mycobacterium smegmatis

Share to Palmitic Acid

Share to Phosphatidylinositols

Share to Spectrometry, Mass, Electrospray Ionization

Source

Identifiers

PMID: 12851411
DOI: 10.1074/jbc.M303639200

Genes

GPI
PIM1
PIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.PMID 12851411Read ↗

Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophagesSemantic proximity Read ↗

Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria.Semantic proximity Read ↗

Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.Semantic proximity Read ↗

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.Semantic proximity Read ↗

Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae.Semantic proximity Read ↗

Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant.Semantic proximity Read ↗

Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.Semantic proximity Read ↗

Phosphatidylinositol is an essential phospholipid of mycobacteria.Semantic proximity Read ↗

Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.Semantic proximity Read ↗

Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria.Semantic proximity Read ↗

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimESemantic proximity Read ↗

Characterization of key enzymes involved in triacylglycerol biosynthesis in mycobacteria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.