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Article

Olorin: combining gene flow with exome sequencing in large family studies of complex disease.

Bioinformatics (Oxford, England) - 15 Dec 2012

Morris James A, Barrett Jeffrey C

Abstract excerpt

MOTIVATION: The existence of families with many individuals affected by the same complex disease has long suggested the possibility of rare alleles of high penetrance. In contrast to Mendelian diseases, however, linkage studies have identified very few reproducibly linked loci in diseases such as diabetes and autism. Genome-wide association studies have had greater success with such diseases, but these results...

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Identifiers

PMID: 23052039
DOI: 10.1093/bioinformatics/bts609
PMCID: PMC3519455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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