Article
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
The Journal of experimental medicine - 15 Jan 2001
Goulder P J, Altfeld M A, Rosenberg E S, Nguyen T, Tang Y, Eldridge R L, Addo M M, He S, Mukherjee J S, Phillips M N, Bunce M, Kalams S A, Sekaly R P, Walker B D, Brander C
Abstract excerpt
Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused on CTL specificities in chronic infection and few data exist regarding the specificity of the initial CTL response induced in acute infection. In this study, HIV-1 infection in persons expressing human histocompatibility leukocyte antigen (HLA)-A*0201 was...
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