Article
Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens.
Gut - 1 Nov 2010
Müller Stefan, Schaffer Thomas, Flogerzi Beatrice, Seibold-Schmid Beatrice, Schnider Jasmin, Takahashi Kazue, Darfeuille-Michaud Arlette, Vazeille Emilie, Schoepfer Alain M, Seibold Frank
Abstract excerpt
BACKGROUND: In Crohn's disease (CD) the deficiency of mannan-binding lectin (MBL) is associated with an increased prevalence of anti-Saccharomyces cerevisiae antibodies (ASCA) and with complicated phenotypes of the disease. However, the role of MBL in intestinal inflammation is currently unclear. A study was undertaken to analyse local MBL expression in human intestine and the consequences of MBL deficiency in...
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