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Article

Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients.

Scientific reports - 12 Jul 2016

Choteau Laura, Vasseur Francis, Lepretre Frederic, Figeac Martin, Gower-Rousseau Corine, Dubuquoy Laurent, Poulain Daniel, Colombel Jean-Frederic, Sendid Boualem, Jawhara Samir

Abstract excerpt

Mannose-binding lectin, together with mannose-associated serine proteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms. An association between mannose-binding lectin deficiency and anti-Saccharomyces cerevisiae antibody levels is observed in Crohn's disease and this deficiency is frequently associated with a severe Crohn's disease phenotype. In the present study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mannose-Binding Protein-Associated Serine Proteases

Share to Nod2 Signaling Adaptor Protein

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 27404661
DOI: 10.1038/srep29636
PMCID: PMC4940739

Genes

MBL2
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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