Article
Low Mannan-binding lectin serum levels are associated with complicated Crohn's disease and reactivity to oligomannan (ASCA).
The American journal of gastroenterology - 1 Oct 2009
Schoepfer Alain M, Flogerzi Beatrice, Seibold-Schmid Beatrice, Schaffer Thomas, Kun Jürgen F J, Pittet Valerie, Mueller Stefan, Seibold Frank
Abstract excerpt
OBJECTIVES: Mannan-binding lectin (MBL) acts as a pattern-recognition molecule directed against oligomannan, which is part of the cell wall of yeasts and various bacteria. We have previously shown an association between MBL deficiency and anti-Saccharomyces cerevisiae mannan antibody (ASCA) positivity. This study aims at evaluating whether MBL deficiency is associated with distinct Crohn's disease (CD)...
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