p53 in chronic myelogenous leukemia in acute phase.

doi:10.1073/pnas.88.14.6293

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Article

p53 in chronic myelogenous leukemia in acute phase.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991

Feinstein E, Cimino G, Gale R P, Alimena G, Berthier R, Kishi K, Goldman J, Zaccaria A, Berrebi A, Canaani E

Abstract excerpt

All patients with chronic myelogenous leukemia (CML) undergo clinical transition from chronic to acute phase. This transition is often associated with deletion of the short arm of chromosome 17 in the form of the i(17q) aberration. Since the p53 gene is a suppressor gene and is located on 17p13, we examined the possibility that it is inactivated during progression of CML. Therefore, we studied the structure and...

Topics

Base Composition
Base Sequence
Cell Line
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Gene Rearrangement
Genes, Tumor Suppressor
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Structural

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

RNA, Neoplasm

Restriction Mapping

Translocation, Genetic

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 2068108
DOI: 10.1073/pnas.88.14.6293
PMCID: PMC52069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2068108-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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