Article
Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p.
Cancer research - 1 Dec 1992
Nakai H, Misawa S, Toguchida J, Yandell D W, Ishizaki K
Abstract excerpt
We investigated chromosome alterations and mutations of the p53 gene in 118 samples from 92 patients with chronic myelogenous leukemia in various clinical phases, i.e., chronic phase, accelerated phase, and blast crisis (BC). Single-strand conformation polymorphism analysis and subsequent nucleotide sequencing disclosed no alteration of the p53 gene in chronic phase (no mutation in 80 samples), while five of 31...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Blast Crisis
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- DNA, Single-Stranded
- Female
- Genes, p53
- Heterozygote
- Humans