Article
17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ.
Blood - 1 Feb 1998
Soenen V, Preudhomme C, Roumier C, Daudignon A, Laï J L, Fenaux P
Abstract excerpt
Recently, we and other groups reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) a strong correlation between cytogenetic rearrangements leading to 17p deletion, a typical form of dysgranulopoiesis combining pseudo-Pelger-Huët hypolobulation and small vacuoles in neutroph...
Topics
- Adult
- Aged
- Aged, 80 and over
- Chromosome Banding
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 5
- Female
- Gene Deletion
- Genes, p53
- Humans
- In Situ Hybridization, Fluorescence
- Leukemia, Myeloid, Acute
- Male
- Middle Aged
- Mutation
- Myelodysplastic Syndromes
- Translocation, Genetic