Monoallelic deletions of the P53 gene in Chinese patients with chronic myelogenous leukemia in blastic crisis.

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Article

Monoallelic deletions of the P53 gene in Chinese patients with chronic myelogenous leukemia in blastic crisis.

Nouvelle revue francaise d'hematologie - 1 Jan 1991

Chen S J, Wang Q, Tong J H, Xie W J, Cao Q, Cai J R, Li X S, Wang Z Y, Chen Z, Larsen C J

Abstract excerpt

The configuration of the P53 tumor suppressor gene was investigated in 43 Chinese patients with chronic myelogenous leukemia (CML), 32 in chronic phase and 11 in blastic crisis. No obvious rearranged DNA band was detected in Southern blot patterns from patients at both stages of the disease. Howe...

Topics

Adult
Aged
Alleles
Blast Crisis
Blotting, Southern
Child
China
Chromosome Deletion
Female
Genes, p53
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Middle Aged

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Open in PubMed

Identifiers

PMID: 1818302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1818302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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