Myelomonocytic crisis with t(5;17) and a p53 mutation in a patient with chronic myelogenous leukemia.

doi:10.1002/ajh.2830450412

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Myelomonocytic crisis with t(5;17) and a p53 mutation in a patient with chronic myelogenous leukemia.

American journal of hematology - 1 Apr 1994

Nakagawa H, Fujii H, Nakai H, Inazawa J, Misawa S

Abstract excerpt

We report a 64-year-old Japanese man with chronic myelogenous leukemia (CML) who expired with myelomonocytic crisis. Cytogenetic analyses of chronic phase (CP) and accelerated phase (AP) cells revealed a Philadelphia chromosome and an isochromosome for the long arm of chromosome 17, i(17q). This...

Topics

Alleles
Blast Crisis
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 5
DNA, Neoplasm
Genes, p53
Humans
In Situ Hybridization
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myelomonocytic, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 8178805
DOI: 10.1002/ajh.2830450412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8178805-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myelomonocytic crisis with t(5;17) and a p53 mutation in a patient with chronic myelogenous leukemia.PMID 8178805Read ↗

Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p.Semantic proximity Read ↗

Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia.Semantic proximity Read ↗

Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations.Semantic proximity Read ↗

Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms.Semantic proximity Read ↗

Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis.Semantic proximity Read ↗

Monoallelic deletions of the P53 gene in Chinese patients with chronic myelogenous leukemia in blastic crisis.Semantic proximity Read ↗

p53 in chronic myelogenous leukemia in acute phase.Semantic proximity Read ↗

Copy number neutral loss of heterozygosity at 17p and homozygous mutations of TP53 are associated with complex chromosomal aberrations in patients newly diagnosed with myelodysplastic syndromes.Semantic proximity Read ↗

Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex karyotypes.Semantic proximity Read ↗

Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia.Semantic proximity Read ↗

Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality.Semantic proximity Read ↗

Chromosome 17 abnormalities and inactivation of the p53 gene in chronic myeloid leukemia and their prognostic significance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.