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Article

Role of p53 in leukemogenesis of chronic myeloid leukemia.

Stem cells (Dayton, Ohio) - 1 Jul 1995

Lanza F, Bi S

Abstract excerpt

This review attempts to provide current information on the role played by the p53 gene in normal and leukemic hematopoiesis with particular emphasis on chronic myeloid leukemia. On the basis of the currently available data we can argue that p53 acts as a negative regulator of proliferation of myeloid mature cells and CD34+ progenitors, and its action is mediated through changes in cell cycle kinetics, mainly...

Topics

Genes, p53
Hematopoiesis
Hematopoietic Stem Cells
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Oligonucleotides, Antisense

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7549904
DOI: 10.1002/stem.5530130416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7549904-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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