Dominant suppression of adenovirus mediated transformation and insufficiency of p105Rb binding as a condition for oncogenic transformation.

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Article

Dominant suppression of adenovirus mediated transformation and insufficiency of p105Rb binding as a condition for oncogenic transformation.

Oncogene - 1 Jun 1991

Weber J M, Sircar S, Rodrigues M, Cai F, Horvath J

Abstract excerpt

An adenovirus-specific transformation resistant cell line (G2) expressing biologically active E1a proteins and originally isolated as a revertant from Ad2-transformed rat cells (F4), was shown to form stable Rb-E1a and 300K-E1a complexes in immunoprecipitation experiments. Consistent with the transformation resistant phenotype, cell hybrids between G2 and F4 were all nontumorigenic. Retrovirus insertion...

Topics

Adenoviruses, Human
Animals
Cell Line
Cell Transformation, Neoplastic
Cell Transformation, Viral
DNA Transposable Elements
DNA, Viral
Fibroblasts
Genes, Dominant
Genes, Retinoblastoma
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybrid Cells

Phenotype

Precipitin Tests

Rats

Retinoblastoma Protein

Suppression, Genetic

Source

Open in PubMed

Identifiers

PMID: 1648705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1648705-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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