Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant suppression of adenovirus mediated transformation and insufficiency of p105Rb binding as a condition for oncogenic transformation.

Oncogene - 1 Jun 1991

Weber J M, Sircar S, Rodrigues M, Cai F, Horvath J

Abstract excerpt

An adenovirus-specific transformation resistant cell line (G2) expressing biologically active E1a proteins and originally isolated as a revertant from Ad2-transformed rat cells (F4), was shown to form stable Rb-E1a and 300K-E1a complexes in immunoprecipitation experiments. Consistent with the transformation resistant phenotype, cell hybrids between G2 and F4 were all nontumorigenic. Retrovirus insertion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA Transposable Elements
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Genes, Dominant

Share to Genes, Viral

Share to Phenotype

Source

Identifiers

PMID: 1648705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant suppression of adenovirus mediated transformation and insufficiency of p105Rb binding as a condition for oncogenic transformation.PMID 1648705Read ↗

Adenovirus E1A-p105(Rb) protein interactions play a direct role in the initiation but not the maintenance of the rodent cell transformed phenotype.Semantic proximity Read ↗

"Hit-and-run" transformation by adenovirus oncogenes.Semantic proximity Read ↗

trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation.Semantic proximity Read ↗

A region in the C‐terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24‐ras mediated transformation, tumorigenesis and metastasis.Semantic proximity Read ↗

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.Semantic proximity Read ↗

Differential requirement for adenovirus type 12 E1A gene products in oncogenic transformation.Semantic proximity Read ↗

How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40Semantic proximity Read ↗

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.Semantic proximity Read ↗

Cell transformation by the adenovirus oncogenes E1 and E4Semantic proximity Read ↗

Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA ReplicationSemantic proximity Read ↗

Wild-type adenovirus type 5 transforming genes function as transdominant suppressors of oncogenesis in mutant adenovirus type 5 transformed rat embryo fibroblast cells.Semantic proximity Read ↗

Comparison between E1A gene from oncogenic and non-oncogenic adenoviruses in cellular transformation (Ad E1A conserved region).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.