Article
CARD15 mutations and colorectal cancer in a South European country.
International journal of colorectal disease - 1 Oct 2010
Freire Paulo, Portela Francisco, Donato Maria M, Figueiredo Pedro, Ferreira Manuela, Amaro Pedro, Sá Anabela, Andrade Paulo, Gouveia Hermano, Sofia Carlos
Abstract excerpt
PURPOSE: CARD15 mutations are associated with higher susceptibility to Crohn's disease (CD) and longstanding colonic CD increases the risk of developing colorectal cancer (CRC). The relation between these mutations and sporadic CRC remains controversial. The aim of this study was to assess whether germline and/or somatic CARD15 mutations are risk factors for sporadic CRC in Portugal and whether there are...
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