Article
Caspase recruitment domain-containing protein 15 mutations in patients with colorectal cancer.
Cancer research - 1 Mar 2006
Roberts Rebecca L, Gearry Richard B, Allington Melanie D E, Morrin Helen R, Robinson Bridget A, Frizelle Frank A
Abstract excerpt
The caspase recruitment domain-containing protein 15 (CARD15) plays a crucial role in mediating the innate immune response. Mutations within this protein have been shown to be independent risk factors for the development of Crohn's disease in Caucasians. As Crohn's disease patients are at increased risk of developing sporadic colorectal cancer, it is conceivable that genetic variability within CARD15 may also...
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