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Distribution of common CARD15 variants in patients with sporadic Crohn's disease: cases from Turkey.

Digestive diseases and sciences - 1 Apr 2006

Uyar F Aytül, Over-Hamzaoğlu Hülya, Türe Filiz, Gül Ahmet, Tözün Nurdan, Saruhan-Direskeneli Güher

Abstract excerpt

Three common genetic variations, namely, R702W, G908R, and 1007fs, on CARD15 have been shown to increase the risk for Crohn's disease (CD) in Caucasian populations. In this study the frequencies of these CARD15 variants were determined by genotyping in 56 patients with CD and 100 healthy ethnically matched controls from Turkey. Overall frequency of all three variants was 10.7% in CD patients, compared with 1.5%...

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Cohort Studies
Confidence Intervals
Crohn Disease
Gene Expression Regulation
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PMID: 16614992
DOI: 10.1007/s10620-006-3195-y

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