Article
CARD15 mutation analysis in an Italian population: Leu1007fsinsC but neither Arg702Trp nor Gly908Arg mutations are associated with Crohn's disease.
Inflammatory bowel diseases - 1 Mar 2004
Vavassori Piero, Borgiani Paola, Biancone Livia, D'Apice Maria Rosaria, Blanco Giovanna Del Vecchio, Vallo Laura, De Nigris Francesca, Monteleone Ivan, Monteleone Giovanni, Pallone Francesco, Novelli Giuseppe
Abstract excerpt
BACKGROUND: CARD15 gene mutations have been demonstrated to confer a high risk of Crohn's disease (CD). Despite this, recent studies reported variable associations between CD and CARD15 mutations in distinct ethnic groups, thus raising the hypothesis that genetic and/or allelic heterogeneity may influence the relationship between CARD15 and CD. The purpose of this study was to evaluate the frequency of the main...
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