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Article

Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.

BMC gastroenterology - 20 Oct 2009

Möckelmann Nikolaus, von Schönfels Witigo, Buch Stephan, von Kampen Oliver, Sipos Bence, Egberts Jan Hendrik, Rosenstiel Philip, Franke Andre, Brosch Mario, Hinz Sebastian, Röder Christian, Kalthoff Holger, Fölsch Ulrich R, Krawczak Michael, Schreiber Stefan, Bröring Clemens Dieter, Tepel Jürgen, Schafmayer Clemens, Hampe Jochen

Abstract excerpt

BACKGROUND: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated...

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Identifiers

PMID: 19843337
DOI: 10.1186/1471-230X-9-79
PMCID: PMC2776017

Genes

CARD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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