Article
Association between mutations in the CARD15/NOD2 gene and colorectal cancer in a Greek population.
International journal of cancer - 10 Apr 2005
Papaconstantinou Ioannis, Theodoropoulos George, Gazouli Maria, Panoussopoulos Dimitris, Mantzaris Gerassimos J, Felekouras Evangelos, Bramis John
Abstract excerpt
Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example since patients with longstanding IBD are at increased risk for development of colorectal cancer (CRC). Therefore, genetic factors predisposing to or implicated in the chronic inflammatory process in IBD may simultaneously predispose to CRC. Recently CARD15/NOD2 has been...
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