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Article

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research - 1 Jun 2015

Wan Wuzhou, Liu Qian, Lionakis Michail S, Marino Ana Paula M P, Anderson Stasia A, Swamydas Muthulekha, Murphy Philip M

Abstract excerpt

AIMS: Atypical chemokine receptor 1 (Ackr1; previously known as the Duffy antigen receptor for chemokines or Darc) is thought to regulate acute inflammatory responses in part by scavenging inflammatory CC and CXC chemokines; however, evidence for a role in chronic inflammation has been lacking. Here we investigated the role of Ackr1 in chronic inflammation, in particular in the setting of atherogenesis, using the...

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Adoptive Transfer
Aorta
Chemokine CCL2
Chemokine CXCL1
Diet, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Duffy Blood-Group System

Inflammation Mediators

Plaque, Atherosclerotic

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Identifiers

PMID: 25858253
DOI: 10.1093/cvr/cvv124
PMCID: PMC4447808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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