Article
Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 2014
Wang Wang, Patel Vaibhav B, Parajuli Nirmal, Fan Dong, Basu Ratnadeep, Wang Zuocheng, Ramprasath Tharmarajan, Kassiri Zamaneh, Penninger Josef M, Oudit Gavin Y
Abstract excerpt
UNLABELLED: Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1-7 thereby negatively regulating the renin-angiotensin system. However, heart disease in humans and in animal models is associated with only a partial loss of ACE2. ACE2 is an X-linked gene; and as such, we tested the clinical relevance of a partial loss of ACE2 by using female ACE2(+/+) (wildtype) and ACE2(+/-) (heterozygote) mice....
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