Article
Lack of association between poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population.
Rheumatology international - 1 Jan 2012
Lee Kyeong-A, Bang So-Young, Park Byung Lae, Kim Jeong-Hyun, Shin Hyoung Doo, Bae Sang-Cheol
Abstract excerpt
Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic...
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