Article
Rheumatoid arthritis risk associates with DNA repair gene XRCC1 Arg399Gln polymorphism in Turkish patients.
Rheumatology international - 1 May 2012
Yosunkaya Elif, Karakurt Funda, Cetin Esra, Ozgonenel Levent, Onaran Ilhan, Batar Bahadir, Guven Mehmet, Sultuybek Gonul Kanigur
Abstract excerpt
Rheumatoid arthritis (RA) is an autoinflammatory disease with a genetic background. The synoviocytes in RA shows cellular transformation with tumor-like features, and RA patients have genomic instability and relaxation of DNA repair mechanisms. The polymorphisms in BER repair pathway genes, XRCC1 and OGG1, may change the response to inflammation via altered DNA repair capacity. In this study, we aimed to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
