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The Role of Poly(ADP‐ribose) Polymerase‐1 in Rheumatoid Arthritis

1 Jan 2015

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a...

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PMID: 26339143
DOI: 10.1155/2015/837250

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