Lack of tumor necrosis factor alpha gene polymorphism -857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients.

doi:10.1111/1756-185X.12857

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Lack of tumor necrosis factor alpha gene polymorphism -857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients.

International journal of rheumatic diseases - 1 Nov 2016

Sadaf Tayyaba, John Peter, Bhatti Attya, Jahangir Sidrah, Kiani Aysha K, Gill Farah A, Malik Javed M

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is a common systemic autoimmune disease, influenced greatly by the pro-inflammatory cytokine tumor necrosis factor- alpha (TNF-α). Single nucleotide polymorphisms (SNPs) in regulatory regions of the TNF-α gene play a significant role in disease development and pathogenesis. The aim of this study was to investigate the association of TNF-α -857C/T (rs1799724) SNP with RA...

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PMID: 27126784
DOI: 10.1111/1756-185X.12857

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