Article
A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans.
Arthritis and rheumatism - 1 Jan 2006
Kang Changsoo Paul, Lee Hye-Soon, Ju Hyoungseok, Cho Hyunmi, Kang Changwon, Bae Sang-Cheol
Abstract excerpt
OBJECTIVE: Anticitrullinating autoantibodies are specific markers for rheumatoid arthritis (RA). A functional haplotype of 4 exonic single-nucleotide polymorphisms (SNPs) in a citrullinating enzyme, peptidylarginine deiminase 4 (PADI4), was shown to be associated with susceptibility to RA in a Japanese population and was shown to increase the stability of PADI4 messenger RNA. However, the association was not...
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