Article
Cyclooxygenase-2 polymorphisms and risk of rheumatoid arthritis in Koreans.
The Journal of rheumatology - 1 May 2008
Yun Hye-Ryeon, Lee Soo-Ok, Choi Eun Ju, Shin Hyoung Doo, Jun Jae-Bum, Bae Sang-Cheol
Abstract excerpt
OBJECTIVE: To determine the association of single-nucleotide polymorphisms (SNP) in the cyclooxygenase-2 (COX-2) gene with the risk and radiologic severity of rheumatoid arthritis (RA) in Koreans. METHODS: Sequencing of the COX-2 gene using a DNA analyzer revealed genetic variants in 24 Korean DNA samples. A total of 1201 Korean patients with RA and 973 controls were genotyped using the TaqMan method. HLA-DRB1...
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