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The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.

Rheumatology international - 1 May 2009

Onaran Ilhan, Tezcan Gülçin, Ozgönenel Levent, Cetin Esra, Ozdemir Alper Tunga, Kanigür-Sultuybek Gönül

Abstract excerpt

The findings of the studies on poly(ADP-ribose) polymerase-1 (PARP-1) have suggested that the enzyme inactivation provides significant protection against systemic or tissue inflammation in animal models. It has also shown that the single-nucleotide polymorphism (Val762Ala) of the PARP-1 causes about 40% decrease of enzyme activity. The aim of this study was to analyze the association of the PARP-1 Val762Ala...

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Identifiers

PMID: 19030862
DOI: 10.1007/s00296-008-0772-8

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The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.PMID 19030862Read ↗

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