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Investigation of poly (ADP-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis.

Genetic testing and molecular biomarkers - 1 Jan 2014

Ozaydin Ahmet, Akbas Fahri, Aksoy Fadlullah, Yildirim Yavuz Selim, Demirhan Hasan, Karakurt Funda, Koc Arzuhan, Onaran Ilhan, Kanigur Sultuybek Gonul

Abstract excerpt

Recent studies point toward the involvement of poly (ADP-ribose) polymerase-1 (PARP-1) in the pathogenesis of allergic airway inflammation, such as asthma and allergic rhinitis (AR). It has been suggested that inhibition of PARP-1 provides significant protection against systemic or tissue inflammation in animal models. The objective of this study was to investigate whether single-nucleotide polymorphisms of...

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PMID: 24180296
DOI: 10.1089/gtmb.2013.0363

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