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Article

SUMO targets the APC/C to regulate transition from metaphase to anaphase

12 Mar 2018

Abstract excerpt

Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master...

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PMID: 29549242
DOI: 10.1038/s41467-018-03486-4

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Related research

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SUMO targets the APC/C to regulate transition from metaphase to anaphasePMID 29549242Read ↗

Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast.Semantic proximity Read ↗

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Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

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Conjugation of Human Topoisomerase 2α with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain SpecificitySemantic proximity Read ↗

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